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Toxicity. Jiaohua Luo, Weiqun Shu, in Handbook of Arsenic Toxicology, 2015. 15.1 Introduction. Arsenic toxicity has become a global health problem affecting millions of people. Aside from causing gastrointestinal, respiratory, cardiovascular, genitourinary, endocrine, hematopoietic system and skin diseases , acute and chronic arsenic exposure is associated with neurologic consequences in adults ..